Enhancing Effect and Action Mechanism of Interleukin-4 Production in Activated T Cells by Phytoestrogens

  • Park, Jin (College of Pharmacy, Chonnam National University) ;
  • Kim, Tae-Sung (College of Pharmacy, Chonnam National University)
  • Published : 2003.10.01

Abstract

Phytoestrogens are naturally occurring compounds derived from plants. Structurally, some phytoestrogens resemble endogenous estrogen of humans and animals. Phytoestrogens exhibit estrogen agonist/antagonist properties and have many biological effects such as prevention of hormone-dependent breast cancer, anti-oxidative activity, inhibition of tyrosine kinase activities and inhibition of angiogenesis. In this study we investigated whether biochanin A, a phytoestrogen, and its metabolites such genistein, p-ethylphenol and phenolic aic affect IL-4 production in EL-4 thymoma cell-line and primary lymph node cells. (omitted)

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