대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.125.2-125.2
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- 2003
LPS-induced Imbalanced Expression of Hepatic Vascular Stress in Hepatic Ischemia and Reperfusion
- Kim, Sung-Ho (College of Pharmacy, Sungkyunkwan University) ;
- Park, Sun-Mee (College of Pharmacy, Sungkyunkwan University) ;
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Lee, Sun-Mee
(College of Pharmacy, Sungkyunkwan University)
- 발행 : 2003.10.01
초록
Hepatic ischemia and reperfusion predisposes the liver to secondary stresses such as endotoxemia possibly via dysregulation of the hepatic microcirculation secondary to imbalanced regulation of vascular stress gene. In this study, we determined the effect of endotoxin on hepatic vasoregulatory gene expression in response to hepatic ischemia and reperfusion (I/R). Rats were subjected to 90 min of hepatic ischemia and 6 h of reperfusion. Lipopolysaccharide (LPS, 1 mg/kg) was injected intraperitoneally after reperfusion. (omitted)
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