대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- /
- Pages.117.3-118
- /
- 2003
New HDAC inhibitor, IN2001 induces apoptosis/cell cycle arrest in human breast cancer cells
- Joung, Ki-Eun (Ewha Womans University, College of Pharmacy) ;
- Min, Kyung-Nan (Ewha Womans University, College of Pharmacy) ;
- Cho, Min-Jung (Ewha Womans University, College of Pharmacy) ;
- An, Jin-Young (Ewha Womans University, College of Pharmacy) ;
- Kim, Dae-Ki (Ewha Womans University, College of Pharmacy) ;
- Sheen, Yhun-Yhong (Ewha Womans University, College of Pharmacy)
- 발행 : 2003.10.01
초록
The acetylation of histone is one of the mechanisms involved in the regulation of gene expression and is tightly controlled by two core enzymes, histone acetyltransferase (HAT) and deacetylase (HDAC). There are several reports that imbalance of HAT and HDAC activity is associated with abnormal behavior of the cells in morphology, cell cycle, differentiation, and carcinogenesis. Recently, an increasing number of structurally diverse HDAC inhibitors have been identified that inhibit proliferation and induce differentiation and/or apoptosis of tumor cells in vivo and in vitro. (omitted)
키워드