대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
- /
- Pages.98.1-98.1
- /
- 2003
Anti-inflammatory mechanism of bee vemon in Raw 264.7 cells and Synoviocyte
- Hwang, In-Young (College of Pharmacy, Chungbuk National University) ;
- Park, Hye-Ji (College of oriental Medicine, Kyungwon University) ;
- Kim, Kee-Hyun (KRIB) ;
- Lee, Seung-Ho (KRIB) ;
- Oh, Goo-Taeg (KRIB) ;
- Hong, Jin-Tae (KRIBB)
- 발행 : 2003.10.01
초록
Bee venom (BY) has been utilized to relieve pain and to treat inflammatory diseases such as rheumatoid arthritis (RA). However, the molecular mechanism by which BV-induced anti-arthritis effect has been not reported yet. Therefore, in the present study we investigated anti-inflammatory effect of BV in a murine marcrophage cell line Raw 264.7 cell and synoviocyte obtained from RA patients. The present data showed that BV has a preventive effect on lipopolysaccharide (LPS) and sodium nitroprusside (SNP) induced induction of COX-2, cPLA2 and iNOS. (omitted)
키워드