Antidiabetic Activity of Formular containing an Euonymus alata and Mori Foluim in Multiple Low Dose Streptozotocin-induced Rats

  • Chung, Sung-Hyun (laboratory of Pharmacology, School of Pharmacy, Kyung Hee University) ;
  • Lee, Sung-Hyun (Laboratory of Pharmacology, School of Pharmacy, Kyung He University) ;
  • Kim, Hee-Ja (Laboratory of Pharmacology, School of Pharmacy, Kyung He University)
  • Published : 2003.10.01

Abstract

Antidiabetic activity of formular containing an Euonymus alata (EA) and Mori Foluim (MF) was investigated in oral glucose tolerance test (OGTT) and multiple low dose Streptozotocin (MLDSTZ)-induced rats. Optimum ratio between EA and MF was found to be 1:1 in OGTT, and two strengths (250 and 500 mg/kg for each medicinal plant) were coadministered with 20 mg/kg of STZ in 5 consecutive days. At 3rd week, water and food intakes were compared between groups and polydipsia and polyphagia shown in diabetic control were markedly improved in dose dependent manner. (omitted)

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