Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Chronic administration of quercetin in rats causes the suppression of glutathione metabolism

  • Choi, Eun-Jeong (Korea University, Department of Biotechnology, Korea Research Institute Chemical Technology, Medicinal Science Division) ;
  • Chee, Kew-Mahn (Korea University, Department of Biotechnology, Korea Research Institute Chemical Technology, Medicinal Science Divisio) ;
  • Lee, Byung-Ho (Korea University, Department of Biotechnology, Korea Research Institute Chemical Technology, Medicinal Science Division)
  • Published : 2003.10.01
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Abstract

The present study was performed to investigate the effects of chronic administration of quercetin on lipid peroxidation and glutathione concentrations in rat liver. Male Sprague-Dawley rats were divided into two groups, one of which was fed a normal diet and the other a vitamin E-free diet. Each of these groups was divided further into three subgroups and treated with quercetin administered orally at either 2 or 20 mg/day or with vehicle for four weeks. The concentrations of ${\alpha}$-tocopherol in serum and liver increased following quercetin treatment, and these increases were significantly greater in rats maintained on vitamin E-free diet. (omitted)

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