대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.78.1-78.1
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- 2003
Sauchinone, a Lignan from Saururus chinensis, Suppresses iNOS Expression through the Inhibition of Transactivation Activity of RelA of NF-kB
- June, Haeng-Sun (KRIBB) ;
- Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University) ;
- Lee, Jeong-Hyung (College of Pharmacy, Chungbuk National University) ;
- Hong, Young-Soo (College of Pharmacy, Chungbuk National University) ;
- Lee, Jung-Joon (College of Pharmacy, Chungbuk National University)
- 발행 : 2003.10.01
초록
Sauchinone, a known lignan, was isolated from the root of Saururus chinensis as an active principle responsible for inhibiting the production of NO in LPS-stimulated RAW264.7 cells by activity-guided fractionation. Sauchinone dose-dependently inhibited not only the production of NO, but also the expression of iNOS mRNA and protein in LPS-stimulated RAW 264.7 cells. Furthermore, sauchinone prevented LPS-induced NF-kB activation, which is known to play a critical role in iNOS expression, assessed by a reporter assay under the control of NF-kB. (omitted)
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