Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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The mechanism of sphingosine-1-phosphate induced contraction in cat esophageal smooth muscle cells.

  • Choi, Tae-Sik (Dept. of Pharmacology, Coll. of pharmacy, Chung Ang University) ;
  • Lee, Tai-Sang (Dept. of Pharmacology, Coll. of pharmacy, Chung Ang University) ;
  • Woo, Jae-Gwang (Dept. of Pharmacology, Coll. of pharmacy, Chung Ang University) ;
  • Kim, Yong-Sung (Dept. of Pharmacology, Coll. of pharmacy, Chung Ang University) ;
  • Sohn, Uy-Dong (Dept. of Pharmacology, Coll. of pharmacy, Chung Ang University)
  • Published : 2003.10.01
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Abstract

We previously shown that sphingosylphosphorylcholine, a lysophosphatidic acid, produced contraction in isolated single cells of cat ilium. We investigated the mechanism of sphingosine-1-phosphate (S1P)-induced contraction of circular smooth muscle cells in cat esophagus. S1P produced esophageal contraction in a dose dependent manner. The maximal contraction (l0$\^$-7/ M) induced at 1min. Pertusis toxin (PTX) inhibited contraction induced by S1P, suggesting that the contraction is mediated to a PTX-sensitive G-protein. (omitted)

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