Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Mitogen-activated protein kinase signaling pathway mediates 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced apoptosis in Jurkat T cells.

  • Kwon, Myung-Ja (Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University) ;
  • Jeong, Kyu-Shik (Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University) ;
  • Choi, Eun-Jeong (Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University) ;
  • Lee, Byung-Ho (Korea Research Institute of Chemical Technology, Medicinal Science Division, Kyungpook National University)
  • Published : 2003.10.01
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Abstract

The present study was performed to examine mitogen-activated protein kinase associated pathways in mediation of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced cell apoptosis in cultured Jurkat T cells. TCDD significantly decreased cell viability in a concentration-dependent manner (p<0.05 at 10-300 nM). TCDD (10 nM) also time-dependently decreased cell viability (p<0.05 at 12-48 h). c-Jun NH$_2$-terminal kinase was significantly phosphorylated with TCDD treatment in a time dependent manner. (omitted)

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