대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.69.1-69.1
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- 2003
Dihydrosphingosine 1-phosphate: New Biomarker for Fumonisin B1 Toxicity
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Lee, Yong-Moon
(College of Pharmacy, Chungbuk National University)
;
- Yoo, Hwan-Soo (College of Medicine, Ehwa University) ;
- Oh, Sei-Kwan (Faculty of Pharmaceutical Sciences, Hokkaido University) ;
- Lee, Eun-Young (Faculty of Pharmaceutical Sciences, Hokkaido University) ;
- Kihara, Akio (Faculty of Pharmaceutical Sciences, Hokkaido University) ;
- Igarashi, Yasuyuki (Faculty of Pharmaceutical Sciences, Hokkaido University)
- 발행 : 2003.10.01
초록
Fumonisins are a family of mycotoxins produced from Fusarium verticillioides. Most of fumonisin B1 (FB1) toxicities can be explained by its ability to alter sphingolipid metabolism by inhibiting ceramide synthase. At least, the elevation in dihydrosphingosine (DHS) mediates the earliest toxicity of FB1. Some tissues such as kidney and liver, may be most affected by FB1 because they shows high rates of de novo sphingolipid synthesis. Recent review on FB1 toxicity by A.H. Merrill Jr. et al. suggested the possible role of dihydrosphingosine 1-phosphate (dihydroS1P), which sometimes elevated in cell- or tissue specific manners. (omitted)
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