대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.65.1-65.1
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- 2003
A versatile biomimetic total synthesis of benzo[c]phenanthridine and protobeberine alkaloids using lithiated toluamide-benzonitrile cycloaddition
- Le, Thanh-Nguyen (College of Pharmacy, Chonnam National University) ;
- Kang, Sung-Kyung (College of Pharmacy, Chonnam National University) ;
- Cho, Won-Jea (College of Pharmacy, Chonnam National University)
- 발행 : 2003.10.01
초록
Natural benzo[c]phenanthridine and protoberberine alkaloids which have been attractive to synthetic organic chemists and biochemists over the last 2 decades since such compounds have shown interesting biological properties such as antitumor, antiviral and antimicrobacterial activities. For the systematic research on these alkaloids, several total syntheses of these alkaloids have been reported. However, the bulk of reported benzo[c]phenanthridine synthetic studies to date have involved multistep sequences for assembly of the target molecules as well as lack of generality for synthesizing substituted molecules. (omitted)
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