대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.315.2-316
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- 2003
Synthesis and characterization of transferrin-polyethylenimine conjugate for targeted gene delivery
- Lee, Kyung-Man (College of Pharmacy, Chonnam National University) ;
- Kim, In-Sook (College of Pharmacy, Chonnam National University) ;
- Shin, Sang-Chul (College of Pharmacy, Chonnam National University) ;
- Oh, In-Joon (College of Pharmacy, Chonnam National University)
- 발행 : 2003.04.01
초록
Polyethylenimine (PEI) has been used as a non-viral gene delivery carrier. To improve the efficacy of transfection, transferrin was incorporated by covalent linkage to PEI. As a model plasmid DNA, pHME185/b-gal, a mammalian expression vector was used. The transferrin-polyethylenimine (TfPEI) was synthesized by conjugate PEI with transferrin using sodium periodateand and characterized by FT-IR and 1H-NMR. (omitted)
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