Kinetic behavior of sophoricoside by gas chromatography/mass spectrometry in rats

  • Jean, Hee-Kyung (Toxicology Laboratory, Korea Institute of Science & Technology) ;
  • Choi, Hae-Yeon (Toxicology Laboratory, Korea Institute of Science & Technolog) ;
  • Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science & Technolog) ;
  • Kim, Young-Soo (Toxicology Laboratory, Korea Institute of Science & Technolog) ;
  • Kim, Young-Soo (College of Pharmacy, Chungbuk Natl. Univ) ;
  • Kim, Mi-Kyung (College of Medicine, Chungbuk Natl. Univ) ;
  • Lee, Seung-Ho (College of Pharmacy, Yeungnam Univ) ;
  • Jung, Sang-Hun (College of Pharmacy, Yeungnam Univ.)
  • Published : 2003.04.01

Abstract

Sophoricoside was isolated as the inhibitor of IL-5 bioactivity from Sophora japonica (Leguminosae). To develope as novel anti-allergic drug. kinetic study was performed in rats. Serum concentration of sophoricoside was measured by gas chromatography-mass spectrometry (GC/MS) in male Sprague-Dawley rat (250${\pm}$10g, n=5) after oral administration of sophoricoside (100mg/kg). (omitted)

Keywords