대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
- /
- Pages.310.1-310.1
- /
- 2003
Determination of a histone deacetylase inhibitor SD-2007 by LC/MS and application to a pharmacokinetic study in rats
- Shin, Beom-Soo (College of Pharmacy, Sungkyunkwan University) ;
- Yoon, Chi-Ho (College of Pharmacy, Sungkyunkwan University) ;
- Park, Min-Young (College of Pharmacy, Sungkyunkwan University) ;
- Jun, Yoon-Sik (College of Pharmacy, Sungkyunkwan University)
- 발행 : 2003.04.01
초록
SD-2007 ia an apicidin analogue, possessing a potent histone deacetylase inhibiting activity. A rapid and senstive LC/MS method was developed for the determination of SD-2007 and its major active metabolite. apicidin. in rat serum. SD-2007 and apicidin was extracted by liquid-liquid extraction using methyl t-butyl ether. SD-2007 and apicidin were monitored in a SIM mode at m/z of 679 and 622, respectively. (omitted)
키워드