Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.309.2-310
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- 2003
Effect of Intravenous Infusion Time on the Pharmacokinetics and Pharmacodynamics of the Same Total Dose of Torasemide in Rabbits
- Kim, Yu-Chul (College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University) ;
- Lee, Myung-Gull (Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Kangnung National University) ;
- Kim, So-Hee (Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Kangnung National University)
- Published : 2003.04.01
Abstract
The pharmacokinetics and pharmacodynamics of torasemide were evaluated after an intravenous administration of the same total dose of torasemide at a dose of 1 mg/kg to rabbits with different infusion times, 1 min (treatment I), 30 min (treatment II), and 2 h (treatment III). The loss of water and electrolytes in urine induced by torasemide was immediately replaced with infusion of equal volume of lactated Ringer…s solution. (omitted)
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