대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.308.2-309
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- 2003
Effects of Glucose Supplementation on the Pharmacokinetics of Intravenous Chlorzoxazone in Rats with Water Deprivation for 72 Hours
- Kim, Yu-Chul (College of Pharmacy, Seoul National University) ;
- Kim, Eun-Jung (Department of Diagnostic Pathology, College of Medicine, University of Ulsa) ;
- Lee, In-Chul (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
- Kim, Sang-Geon (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
- Lee, Myung-Gull (Department of Pharmacology, College of Dentistry, Kangnung National University) ;
- Kim, So-Hee (Department of Pharmacology, College of Dentistry, Kangnung National University)
- 발행 : 2003.04.01
초록
In rats with water deprivation for 72 h (rats with dehydration), hepatic cytochrome P450 2E1 (CYP2E1) was 3-fold induced with an increase in mRNA, and glucose supplementation instead of food during 72-h water deprivation inhibited the CYP2E1 induction. Chlorzoxazone (CZX) is metabolized to 6-hydroxychlorzoxazone (OH-CZX) mainly by CYP2E1 in rats. (omitted)
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