Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.307.1-307.1
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- 2003
PK/PD Modeling for Glucose-lowering Effect of Metformin in Korean Volunteers
- Lee, Shin-Hwa (College of Pharmacy, Chungnam National University) ;
- Yun, Min-Hyuk (College of Pharmacy, Chungnam National University) ;
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Kwon, Kwang-Il
(College of Pharmacy, Chungnam National University)
- Published : 2003.04.01
Abstract
Metfotrmin is a biguanide antihyperglycemic agent often used for the treatment of non-insulin dependent diabetics(NIDDM). Metformin lowers both fasting and postprandial plasma glucose concentrations by improving insulin sensitivity at hepatic and peripheral tissues. The pharmacokinetics and pharmacodynamics of metformin were studied in Korean healthy volunteers at fasting state over 10 hours. (omitted)
Keywords