Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.306.1-306.1
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- 2003
Effect of ketoconazole on the Pharcokinetics of Paclitaxel in Rats
- Choi, Jun-Shik (College of Pharmacy, Chosun University) ;
- Li, Xiuguo (College of Pharmacy, Chosun University) ;
- Lee, Jin-Hwan (College of Pharmacy, Chosun University)
- Published : 2003.04.01
Abstract
The purpose of this study was to investigate the effect of ketoconazole(20mg/kg) on the pharmacokinetic parameters and the bioavailability of paclitaxel(40mg/kg) orally coadministered in rats. The plasma concentration of paclitaxel in combination with ketoconazole was increased significantly (coadministration p<0.05, pretreatment p<0.01) compared to that of control. (omitted)
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