대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.299.2-300
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- 2003
Preparation and Evaluation of Bupivacaine-loaded Microspheres by Solvent Extraction Method
- Kim, Min-Soo (College of Pharmacy, Chungnam National University) ;
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Hwang, Sung-Joo
(College of Pharmacy, Chungnam National University)
- 발행 : 2003.04.01
초록
Various bupivacaine-Ioaded microspheres were prepared with poly (d,l-Iactide) (PLA) by solvent extraction method. The internal solution of polymer(PLA R104) and drug in glacial acetic acid was introduced into the external phase of polyvinylpyrrolidone (PVP K-30) in polyethyleneglycol (PEG), and emulsified to be an oil-in-oil (o/o) emulsion. The o/o emulsion was poured to the buffer solution. (omitted)
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