Formulation and sustained release of acetaminophen hydroxypropylmethylcellulose(HPMC) matrix tablet

  • Published : 2003.04.01

Abstract

Purpose. To develop a new heterodisperse 650mg acetaminophen HPMC matrix tablet with biphasic sustained release profiles. Methods. Hydroxypropylmethylcellulose(HPMC) matrix tablets were prepared by wet-granulating drug with other excipients, followed by direct compression of the dried granule mixtures into tablet using a rotary tablet machine. (omitted)

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