Determination of nucleosides in human urine by high-performance liquid chromatography with electrospray ionization mass spectrometry(LC/ESI-MS)

  • Published : 2003.04.01

Abstract

Oxidative DNA damage has been associated with many disease. Quantation of DNA adducts is considered to be a useful biomarker of oxidative DNA damage because its formation can also be induced by oxidative stress. Extensive efforts have been taken to identify the analytical methods for minimizing the artifactual formation of oxidative DNA damage. We have done direct analysis of DNA adducts using LC/ESI-MS without urine sample extraction. (omitted)

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