Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.286.1-286.1
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- 2003
MODULATION OF THE ACTIVITY OF PRO-INFLAMMATORY ENZYMES, COX-2 AND iNOS, BY CHRYSIN DERIVATIVES
- Cho, Hee-Yeong (Pharmaceutical Screening Team,. Korea Research Institute of Chemical Technology) ;
- Yun, Cheol-Won (College of Pharmacy, Seoul National University) ;
- Kong, Jae-Yang (College of Pharmacy, Seoul National University) ;
- Kim, Kyoung-Soon (College of Pharmacy, Seoul National University) ;
- Park, You-Mie (College of Pharmacy, Seoul National University) ;
- Lee, Sang-Hyun (College of Pharmacy, Seoul National University) ;
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Kim, Bak-Kwang
(College of Pharmacy, Seoul National University)
- Published : 2003.04.01
Abstract
Chrysin, a natural flavone compound contained in plants. has anti-inflammatory activity. Its anti-inflammatory effect has been previously explained in part by the suppression of promoter activities of inducible pro-inflammatory enzymes (cyclooxygenase-2 (COX-2) and inducible nitrogen synthase (iNOS)). Nitrate production triggered by the activation of lipopolysaccharides (LPS) was most highly suppressed by the treatment of chrysin, follwed by 5-hydroxy-7-methoxyflavone (Ch-2), 5,7-diacetylflavone (Ch-4) in cultured Raw 264.7 cells. (omitted)
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