대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.278.3-279
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- 2003
Chromatographic chiral resolution of several racemic drugs containing primary amino moiety on a chiral stationary phase
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Lee, Won-Jae
(College of Pharmacy, Chosun University) ;
- Baek, Chae-Sun (College of Pharmacy, Chosun University) ;
- Jin, Jing-Yu (College of Pharmacy, Chosun University)
- 발행 : 2003.04.01
초록
A chiral stationary phase (CSP) prepared by bonding (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) to aminopropyl silica gel by HPLC was used in resolving several racemic drugs containing primary amino moiety. Most compounds used in this study were resolved on the CSP using 80% methanol in water (V/V) containing 10mM sulfuric acid as a mobile phase. These results on the CSP were compared to those on the similar CSP derived from 18-C-6-TA of the same chiral selector by different connecting method.
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