Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.278.3-279
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- 2003
Chromatographic chiral resolution of several racemic drugs containing primary amino moiety on a chiral stationary phase
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Lee, Won-Jae
(College of Pharmacy, Chosun University)
;
- Baek, Chae-Sun (College of Pharmacy, Chosun University) ;
- Jin, Jing-Yu (College of Pharmacy, Chosun University)
- Published : 2003.04.01
Abstract
A chiral stationary phase (CSP) prepared by bonding (18-crown-6)-2,3,11,12-tetracarboxylic acid (18-C-6-TA) to aminopropyl silica gel by HPLC was used in resolving several racemic drugs containing primary amino moiety. Most compounds used in this study were resolved on the CSP using 80％ methanol in water (V/V) containing 10mM sulfuric acid as a mobile phase. These results on the CSP were compared to those on the similar CSP derived from 18-C-6-TA of the same chiral selector by different connecting method.
Keywords