Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Dopamine $\beta$-Hydroxylase Inhibitory Activity of Chinese Herbal Drugs

  • Sun, Ji-Yeon (Natural Products Research Institute) ;
  • Lee, Jee-Hwan (Natural Products Research Institut) ;
  • Ki, Chan-Young (Natural Products Research Institut) ;
  • Han, Yong-Nam (Natural Products Research Institute, College of Pharmacy, Seoul National University)
  • Published : 2003.04.01
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Abstract

Dopamine ${\beta}$-hydroxylase (DBH) synthesizes norepinephrine from dopamine under the presence of ascorbate as a coenzyme. Dopamine is transported into the vesicles of the varicosity, where the synthesis and the storage of norepinephrine take place. Some drugs such as DBH inhibitors, dopaminergic agonists,etc. are known to assist in treating Parkinson's disease. (omitted)

Keywords