Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
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Hispidin from the Mycelial Cultures of Phellinus linteus Inhibits A $\beta$-Secreatase(BACE1) and proyl endopeptidase

  • Park, In-Hye (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University) ;
  • Kim, Sang-In (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University) ;
  • Jeon, So-Young (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University) ;
  • Lee, Hee-Ju (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University) ;
  • Song, Kyung-Sik (Division of Applied Biology ＆ Chemistry, College of Agriculture ＆ Life Sciences, Kyungpook National University)
  • Published : 2003.04.01
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Abstract

The ${\gamma}$- and ${\beta}$-secretase are one of the most important proteases, which cleave amyloid precursor protein (APP) into neurotoxic A${\beta}$ peptide in Azheimer's type dementia. In the course of screening for anti-dementia agents from natural products, the mycelial culture of mushroom Phellinus linteus showed potent inhibition againt ${\beta}$-secretase (BACE1). (omitted)

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