Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.268.2-269
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- 2003
Inhibitory effects of natural products on lipopolysaccharide-stimulated PGE2 and nitric oxide production in RAW 264.7 cells
- Park, Hye-Jin (College of Pharmacy, Ewha Womans University) ;
- Min, Hye-Young (College of Pharmacy, Ewha Womans University) ;
- Park, Dong-Ki (College of Agriculture, Kon-kuk University) ;
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Lee, Sang-Kook
(College of Pharmacy, Ewha Womans University)
- Published : 2003.04.01
Abstract
Prostaglandins (PGs) and NO (nitric oxide) are important elements to keep homeostasis and host defense system in human beings. When PGs and NO are overproduced by cyclooxygenase-2(COX-2) and inducible nitric oxide synthase (iNOS), respectively, they can cause chronic inflammation, tissue damage, and carcinogenesis. On this line, we are interested in finding agents that can inhibit the production of PGs and NO from natural products for devloping anti-inflammatory and cancer chemopreventive agents. (omitted)
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