대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.259.3-260
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- 2003
Isolation of specific butyrylcholinesterase (BuChE) inhibitors from the rhizome extract of Curcuma zedoaria
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Kim, Young-Sup
(Korea Research Institute of Chemical Technology)
;
- Park, Eun-Kyung (Korea Research Institute of Chemical Technolog) ;
- Heor, Jung-Hee (Korea Research Institute of Chemical Technolog) ;
- Kim, Seong-Kie (Korea Research Institute of Chemical Technolog) ;
- Kim, Jung-Sook (Korea Research Institute of Chemical Technolog) ;
- Choi, Yeon-Hee (Korea Research Institute of Chemical Technolog) ;
- Seo, Jee-Hee (Korea Research Institute of Chemical Technolog) ;
- Lee, Bong-Ho (Korea Research Institute of Chemical Technolog) ;
- Choi, Byoung-Wook (Korea Research Institute of Chemical Technology)
- 발행 : 2003.04.01
초록
Alzheimer's disease(AD) is the most common cause of senile dementia in elderly people and the causes of AD are currently not fully understood. However, AD is generally understood to be associated with reduced levels of acetylcholine in the brain as cholinergic neurons are lost and cholinergic neurotransmission declines. There are growing evidences that two types of cholinesterase(ChE), i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) both play important roles in the regulation of acetylcholine level in brain and thus may have a crucial role in the development and progression of AD. (omitted)
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