대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.250.3-251
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- 2003
Highly efficient ortho-fluoro-dimeric cinchona-derived phase-transfer catalysts
- Park, Hyeung-Geun (College of Pharmacy, Seoul National University) ;
- Jeong, Byeong-Seon (College of Pharmacy, Seoul National University) ;
- Lee, Jeong-Hee (College of Pharmacy, Seoul National University) ;
- Yoo, Mi-Sook (College of Pharmacy, Seoul National University) ;
- Jew, Sang-Sup (College of Pharmacy, Seoul National University)
- 발행 : 2003.04.01
초록
A series of cinchona alkaloid-derived dimeric quaternary ammonium salts were prepared as chiral phase-transfer catalysts by the introduction of various functional groups on the phenyl ligand. Among them. the 2-F-substituted derivative 21 showed the highest enantioselectivity in the alkylation of the glycine anion equivalent 1 (97->99 % ee).
키워드