The Structure-Activity Relationship of Mansonone F, a Potent Anti-MRSA SesQuiterpenoid Quinone: Insights into Minimum Structural Requirements and SAR of C3 position

The resistances to multiple antibiotics of strains of Gram-positive Staphylococci. methicillin-resistant Staphylo coccus aureus (MRSA), are now significant clinical problem. One of the major efforts of our laboratory has been the search and design and synthesis of novel lead compound for the purpose of obtaining highly potent anti-MRSA drug. Towards this end, we have recently reported the isolation of a potent anti-MRSA drug. (omitted)