대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.241.1-241.1
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- 2003
Design, Synthesis, And In Vitro Evaluation of Apio Analogs of Neplanocin A and Aristeromycin
- Lee, Jeong-Ah (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
- Yoo, Byul-Nae (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
- Moon, Hyung-Ryong (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
- Lee, Kang-Man (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
- Jeong, Lak-Shin (Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University)
- 발행 : 2003.04.01
초록
Apio nucleosides whose 4'-hydroxymethyl group moves to 3'-position exhibit interesting biological activity such as antitumor or antiviral activity. On the other hand, neplanocin A and aristeromycin are the representative of the carbocyclic nucleosides and have been recognized as potent inhibitors of S-adenosylhomocysteine hydrolase. Based on these findings. it was of great interest to design apio analogues of neplanocin A and aristeromycin. (omitted)
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