대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.239.2-240
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- 2003
Studies on the Regioselective and Diastereoselective Amination using Chlorosulfonyl Isocyanate (CSI)
- Kim, In-Su (College of Pharmacy, Sungkyunkwan University) ;
- Jung, Young-Hoon (College of Pharmacy, Sungkyunkwan University)
- 발행 : 2003.04.01
초록
We have recently described the novel synthetic method for N-protected amines from various ethers using chlorosulfonyl isocyanate(CSI) and found that the mechanism of our CSI reaction is a competitive reaction of SN1 and SNi mechanism according to the stability of carbocation intermediate. Forthermore. we developed the regioselective and diastereoselective one-pot synthetic method for 1,2-amino alcohol, through the reaction of di-and tribenzyl thers with CSI, and invetigated its mechanism. (omitted)
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