대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.235.2-235.2
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- 2003
Synthesis and Inhibitory Activity against COX-2 Catalyzed Prostaglandin Production of Flavone Analogs
- Tran, Thanh-Dao (College of Pharmacy, Kangwon National University) ;
- Chi, Yeon-Sook (College of Pharmacy, Seoul National University) ;
- Kim, Jeong-Soo (College of Pharmacy, Seoul National University) ;
- Kim, Hyun-Pyo (College of Pharmacy, Seoul National University) ;
- Kim, Sang-Hee (College of Pharmacy, Seoul National University) ;
- Park, Hae-Il (College of Pharmacy, Seoul National University)
- 발행 : 2003.04.01
초록
To decipher the structure-activity relationships of flavones for the inhibition of cyclooxygenase-2 catalyzed prostaglandin production, we synthesized 7-methxoyflavones, 7-hydroxyflavones, 5-methxoyflavones, 5-hydroxyflavones and flavones without any phenol group on A ring. Methoxyflavones were prepared from 2.6- and 2,4-dihydroxyacetophenones in 3 steps. Most of the methxoyflavones were converted to the corresponding hydroxyflavones by the reaction with BBr3 in good yields. (omitted)
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