대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.233.3-234
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- 2003
Novel Heteroaromatic Arylsulfonylimidazolones as Anticancer Agent
- The, Hung-Dang (College of Pharmacy, Chungnam National University) ;
- Lee, Jee-Hyun (College of Pharmacy, Chungnam National University) ;
- Cho, Soo-Hyun (College of Pharmacy, Chungnam National University) ;
- Hong, Chang-Yong (College of Pharmacy, Chungnam National University) ;
- Jeong, Shin-Wu (College of Pharmacy, Chungnam National University) ;
- Jeon, Ki-Wan (College of Pharmacy, Chungnam National University) ;
- Lee, Sung-Bae (College of Pharmacy, Chungnam National University) ;
- Choi, Whan-Geun (College of Pharmacy, Chungnam National University) ;
- Jung, Sang-Hun (College of Pharmacy, Chungnam National University)
- 발행 : 2003.04.01
초록
Novel arylsulfonylimidazolidinones were previously demonstrated to have broad and highly potent cytotoxicities against a wide range of cancer cell line. Among them 4-phenyl-l N-(p-aminobenzoyl)indoline-5-sulfonyl imidazolidinone (PA) was proved to have good pharmacological profile. Recently modification of indoline moiety of PA led us to find new analogs which show better pharmacological profiles compared to PA. (omitted)
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