Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.210.2-211
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- 2003
Inhibitory effects of synthetic isoflavone compounds on IL-5 bioactivity
- Ju, Jung-Hun (College of Pharmacy, Chungbuk National University) ;
- Jung, Sang-Hun (Chungnam National University) ;
- Cho, Soo-Hyun (Yeungnam University) ;
- Dang, The-Hung (KIS) ;
- Lee, Jee-Hyun (KIS) ;
- Kim, Mi-Kyeong (KIS) ;
- Lee, Seung-Ho (KIS) ;
- Ryu, Jae-Chun (KIS) ;
- Min, Kyung-Rak (KIST)
- Published : 2003.04.01
Abstract
Eosinophilic inflammation is the main histological correlate of airway hyperresponsiveness and tissue injury in the pathogenesis of bronchial asthma. Interleukin (IL)-5 appears to be one of main proinflammatory mediators that induce eosinophilic inflammation. Allergic IL -5-deficient mice do not generate eosinophilia in the bone marrow, blood or lung in response to allergen provocation. (omitted)
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