Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.178.2-178.2
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- 2003
Genotoxicity Study of sophoricoside derivatives in mammalian cells system
- Yun, Hye-Jung (Toxicology Laboratory, Korea Institute of Science ＆ Technology) ;
- Kim, Youn-Jung (Toxicology Laboratory, Korea Institute of Science ＆ Technolog) ;
- Kim, Eun-Young (Toxicology Laboratory, Korea Institute of Science ＆ Technolog) ;
- Kim, Young-Soo (College of Pharmacy, Chungbuk Natl. Univ) ;
- Kim, Mi-Kyung (College of Medicine, Chungbuk Natl. Univ) ;
- Lee, Seung-Ho (College of Pharmacy, Yeungnam Univ) ;
- Jung, Sang-Hun (College of Pharmacy, Chungnam Natl. Univ) ;
- Ryu, Jae-Chun (Toxicology Laboratory, Korea Institute of Science ＆ Technology)
- Published : 2003.04.01
Abstract
To develope the novel anti-allergic drug, many sophoricoside derivatives were synthesized. Among these derivatives, JSH-II-3, JSH-Ⅵ-3, JSH-Ⅶ-3, and JSH-Ⅷ-3 were selected and subjected to high throughput toxicity screening (HTTS) because they revealed strong IL-5 inhibitory activity and limitation of Quantity. Mouse lymphoma thymidine kinase (
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