대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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- Pages.154.1-154.1
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- 2003
An improved method to determine hydroxyproline in an immortalized rat liver stellate cell line (HSC-T6)
- Lee, Eun-Su (Graduate School of East-West Medical Science, Kyung Hee University) ;
- Kwak, Wie-Jong (Life Science Center, SK chemical) ;
- Lee, Eung-Seok (College of Pharmacy, Yeungnam University) ;
- Soh, Yun-Jo (Graduate School of East-West Medical Science, Kyung Hee University)
- 발행 : 2003.04.01
초록
Hydroxyproline (HYP) is a post-translational product of proline hydroxylation catalyzed by an enzyme prolyl 4-hydroxylase which plays a crucial role in the synthesis of all collagens, because the 4-hydroxyproline residues are essential for the folding of the newly synthesized collagen polypeptide chains into triple-heical molecules. Considering the role of collagen and its significance in many clinically important diseases such as liver cirrhosis, a great deal of attention has been directed toward the development of an assay at cell-based system. (omitted)
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