대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Effects of adenosine on the development of tolerance to and physical dependence on morphine in mice

  • Kim, Dong-Seuk (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Ahn, Yu-Ri (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Hong, Jin-Tae (Department of Pharmacology, College of Pharmacy, Chungbuk National University) ;
  • Oh, Ki-Wan (Department of Pharmacology, College of Pharmacy, Chungbuk National University)
  • 발행 : 2003.04.01
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초록

This study was performed to investigate the effects of adenosine on the development of tolerance to and physical dependence on morphine. Repeated adminstration of morphine developed tolerance and physical dependence. Adenosine (1, 2 and 4 mg $kg^{-1}$ i.p.) was administered intraperitoneally to mice for 7 days once a day 30 minutes prior to the morphine (10 mg $kg^{-1}$ s.c.). (omitted)

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