Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.04a
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- Pages.127.2-128
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- 2003
Metabolism of Rutaecarpine by Rat Liver Microsomes
- Lee, Sang-Kyu (College of Pharmacy, Yeungnam University) ;
- Lee, Jae-Ick (Bioanalysis and Biotransformation Research Center, KIS) ;
- Jahng, Young-Dong (College of Pharmacy, Yeungnam University) ;
- Chang, Hyeun-Wook (College of Pharmacy, Yeungnam University) ;
- Lee, Eung-Seok (College of Pharmacy, Yeungnam University) ;
- Kim, Dong-Hyun (Bioanalysis and Biotransformation Research Center, KIS) ;
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Jeong, Tae-Cheon
(College of Pharmacy, Yeungnam University)
- Published : 2003.04.01
Abstract
Rutaecarpine is an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa. In addition to its traditional use in treatment of gastrointestinal disorders, rutaecarpine has recently been characterized to have anti-inflammatory activity through cyclooxygenase-2 inhibition. More recently, to develop rutaecarpine as an anti-inflammatory agent, total synthesis of rutaecarpine has successfully been established in our group. (omitted)
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