Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Molecular Mechanism for Methylmercury-induced Toxicity in Kidney and Brain Cells

  • Kim, Dae-Kyong (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University) ;
  • Kang, Mi-Sun (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University) ;
  • Jeong, Ju-Yeon (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University) ;
  • Jung, Sung-Yun (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University) ;
  • Seo, Ji-Heui (Department of Environmental and Health Chemistry, College of Pharmacy, Chung-Ang University) ;
  • Joseph V.Bonventre (Renal Unit, Massachusetts General Hospital-East, Havard Medical School)
  • Published : 2003.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Methylmercury (MeHg) is a ubiquitous environmental toxicant that can be exposed to humans by ingestion of contaminated food including fish and bread. MeHg has been suggested to exert its toxicity through its high reactivity to thiols, generation of arachidonic acid and reactive oxygen species (ROS), and elevation of intracellular $Ca^{2+}$ levels ([$Ca^{2+}$]i). However, the precise mechanism has not been fully defined. (omitted)

Keywords