Development of anti-inflammatory and Anti-allergic Compounds from Medicinal herbs

Mast cell playa crucial role in allergic and inflammatory disease through the exocytosis of preformed granule-associated mediators, such as histamine, serotonin, proteases and the generation of newly synthesized lipid mediators such as, leucotrien (LT) $C_4$ and prostaglandin (PG) $D_2$ in response to crosslinking of high affinity for IgE (Fc$\gamma$RI). New eicosanoids are synthesized by the oxidative metabolism of arachidonic acid, which is generally esterified sn-2 position of the major classes of glycerophospholipids. (omitted)