Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10a
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- Pages.50-53
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- 2003
Strategy on the Development of Acetal$^{\circledR}$ Capsule Containing Poorly Water-soluble Aceclofenac
- Lee, Beom-Jin (Pharm TRI., National Research Laboratory for Bioavailability Control, College of Pharmacy, Kangwon National University)
- Published : 2003.10.01
Abstract
Aceclofenac (AFC) as a model has poor solubility in water, resulting in lower dissolution rate and bioavailability. A solid dispersion (SD) is one of effective methods to enhance the solubility or dissolution rate of various poorly water-soluble drugs. Polyvinylpyrrolidone (PVP) that is a nontoxic, water-soluble and generally applicable pharmaceutical excipient has been widely used as a carrier in the preparation of solid dispersions. (omitted)
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