Proceedings of the Korean Society of Sericultural Science Conference (한국잠사학회:학술대회논문집)

Korean Society of Sericultural Science (한국잠사학회)
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Drosophila GAGA factor-FACT Complex and its Role in Hox Gene Expression

  • Nakayama, Takahiro (Department of Developmental Genetics, National Institute of Genetics, Mishima) ;
  • Shimojima, Tsukasa (Department of Developmental Genetics, National Institute of Genetics, Mishim) ;
  • Okada, Masahiro (Department of Developmental Genetics, National Institute of Genetics, Mishim) ;
  • Ueda, Hitoshi (Department of Developmental Genetics, National Institute of Genetics, Mishim) ;
  • Hirose, Susumu (Department of Developmental Genetics, National Institute of Genetics, Mishima)
  • Published : 2003.10.01
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Abstract

Chromatin structure plays a critical role in the regulation of transcription. Drosophila GAGA factor directs chromatin remodeling to its binding sites. We found that Drosaphiia FACT, a heterodimer of dSPT16 and dSSRPl, is associated with GAGA factor through its dSSRPl subunit, binds to a nucleosome and facilitates GAGA factor-directed chromatin remodeling. Immunostaining of polytene chromosomes revealed colocalization of GAGA factor and FACT in many specific loci. (omitted)

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