Proceedings of the Korean Society of Veterinary Pathology Conference (한국수의병리학회:학술대회논문집)

Korean Society of Veterinary Pathology (한국수의병리학회)
권호 표지

Alcohol Induced Hepatic Degeneration of HCV-Tg Mouse

  • Noh, Dong-hyung (Dept.. of Vet. Pathol., College of Vet. Med., Kyungpook National Univ.) ;
  • Yu, Dae-yeul (Korea Research Institute of Bioscience and Biotechnolog) ;
  • Jeong, Kyu-shik (Dept.. of Vet. Pathol., College of Vet. Med., Kyungpook National Univ.)
  • Published : 2003.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

Hepatitis C virus (HCV) has become a major public health issue and is prevalent in most countries. HCV infection starts frequently without clinical symptoms, and progresses in the majority of patients (70 to 85％) to persistent viremia and chronic hepatitis including cirrhosis and hepatocellularcarcinoma (HCC) [1]. Alcohol is one of the independent cofactors accelerating the development of HCC in chronic hepatitis C patients. This is of great interest because a synergy between excessive alcohol intake and HCV infection has been documented in the development of HCC in chronic hepatitis C patients [2]. The aim of this study is to investigate liver changes in ethanol feeding HCV-transgenic (Tg) mouse and to establish an animal model system. (omitted)

Keywords