Proceedings of the Korean Society of Veterinary Pathology Conference (한국수의병리학회:학술대회논문집)
- 2003.10a
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- Pages.10-10
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- 2003
Trichostatin A Attenuates Airway Inflammation in Mouse Asthma Model
- Park, Jae-hoon (Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
- Oh, Se-woong (Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
- Kang, Min-soo (Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University) ;
- Kwon, Ho-jeong (Department of Bioscience and Biotechnology, Sejong University) ;
- Oh, Goo-taeg (Korea Research Institute of Bioscience and Biotechnolog) ;
- Kim, Dae-yong (Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University)
- Published : 2003.10.01
Abstract
Histone deacetylase (HDAC) inhibition has been demonstrated to change the expressions of a restricted set of cellular genes, T cells have an essential role in the pathogenesis of allergen-induced airway inflammation [1]. In recent studies, it has been demonstrated that treatment with HDAC inhibitors induces a T cell-suppressive effect [2]. The purpose of this study was to determine whether treatment with trichostatin A (TSA), a representative HDAC inhibitor, would reduce the allergen-induced airway inflammation in a mouse asthma model. (omitted)
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