Malignant Schwannoma in F344 Rat

  • Kim, Bang-hyun (National Institute of Toxicological Research, Korea Food and Drug Administration) ;
  • Nam, Ki-taek (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Han, Beom-seok (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Park, Ki-dae (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Cho, Wan-seob (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Jang, Dong-deuk (National Institute of Toxicological Research, Korea Food and Drug Administratio) ;
  • Lee, Kook-kyung (Department of Veterinary Medicine, Cheju National University) ;
  • Kim, Dae-yong (Department of Veterinary Medicine, Seoul National University) ;
  • Yang, Ki-hwa (National Institute of Toxicological Research, Korea Food and Drug Administration)
  • Published : 2003.10.01

Abstract

Schwannoma is a neoplasm of the Schwann cells of the neural sheath [1]. Malignant schwannoma is most commonly seen in the subcutis of the flank or neck area near the salivary glands [2]. It also occurs in the thoracic and abdominal cavities, spinal cord, cranial cavity, the heart, etc. Here, we incidentally found a good case of malignant schwannoma in the subcutis of the lumbar and lumbosacral region in male F344 rat during the carcinogenicity study with diisodecyl phthalate (DIDP). Therefore, we tried to report this case as a good reference of malignant schwannoma. (omitted)

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