Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Effects of ketoconazole on reproductive organs and steroidogenic enzyme

  • Kang, Il-Hyun (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FDA) ;
  • Lee, Su-Jung (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FD) ;
  • Shin, Jae-Ho (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FD) ;
  • Moon, Hyun-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FD) ;
  • Kim, Hyung-Sik (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FD) ;
  • Kim, Tae-Sung (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FD) ;
  • Ki, Ho-Youn (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FD) ;
  • Cho, Hyun-Ju (Endocrine Toxicology Division, National Institute of Toxicological Research, Korea FD) ;
  • Dong, Mi-Sook (Graduate School of Biotechnology, Korea University)
  • Published : 2003.05.01
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Abstract

Ketoconazole is a well-studied drug that blocks fungal growth and testosterone synthesis in humans and rodents by inhibiting the activity of cytochrome P-450 enzymes. But there were no reports that ketoconazole affects on enzymes related to degradation of testosterone. Aromatase converts testosterone to estradiol. Change of aromatase protein level may destroy hormone homeostasis. (omitted)

Keywords