Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.05a
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- Pages.21-22
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- 2003
Molecular epidemiology and cancer susceptibility -Genetic polymorphisms and susceptibility to urothelial cancer-
- Katoh, Takahiko (Department of Public Health, School of Medicine, Miyazaki Medical College)
- Published : 2003.05.01
Abstract
Arylamines are suspected to be the primary causative agent of urothelial cancer in tobacco smoke. In the human liver, arylamines are N-hydroxylated by a cytochrome P450 (CYP) 1A2-catalyzed reaction, which produces a substrate for O-esterification that can be catalyzed by N-acetylatransferases (NAT) or sulfotransferases (SULT). (omitted)
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