대한화장품학회:학술대회논문집 (Proceedings of the SCSK Conference)
- 대한화장품학회 2003년도 IFSCC Conference Proceeding Book II
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- Pages.87-107
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- 2003
The penetration enhancement and the lipolystic effects of TAT-GKH, in both In vitro, Ex vivo, and In vivo.
- Lim, J.M. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Chang, M.Y. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Park, S.G. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Kang, N.G. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Song, Y.S. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Lee, Y.H. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Yoo, Y.C. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Cho, W.G. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Han, S.G. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research) ;
- Kang, S.H. (Skin research group, Cosmetic R&D center, LG Household & Healthcare Research)
- 발행 : 2003.09.01
초록
It was demonstrated that Transactivating transcriptional activator(TAT) protein from HIV-1 shown to enter cells when added to the surrounding media. TAT peptide chemically attached to various proteins was able to deliver these proteins to various cell and even in tissues in mice with high levels in heart and spleen. In this study, the tripeptide GKH(Glycine-Lysine-Histidine) derived from Parathyroid hormone (PTH), which was known as lipolytic peptide, is attached to 9-poly Lysine(TAT) to be used as a cosmetic ingredient for slimming products. When Glycerol release, expressed as extracellular glycerol concentration, is lipolysis index, TAT-GKH at
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