Proceedings of the SCSK Conference (대한화장품학회:학술대회논문집)
- 2003.09a
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- Pages.733-740
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- 2003
Comparative Molecular Similarity Indices Analysis (CoMSIA) on the Melanogenesis Inhibitory Activities of Alkyl-3,4-dihydroxy- benzoate and N-alkyl-3,4-dihydroxybenzamide Derivatives.
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Kim, Sang-Jin
(Dept. of Cosmetic Science, Daejeon Health Sciences College) ;
- Sung, Nack-Do (Division of Applied Biology & Chemistry, College of Agriculture & Life Sciences, Chungnam National University) ;
- Lee, Sang-Ho (Korea Research Institute of Chemical Technology)
- Published : 2003.09.01
Abstract
To find a new substance with superior melanogenesis inhibitory activity, the bioactivities of alkyl-3,4-dihydroxy-5-substituted benzoate (A) and N-alkyl-3,4-dihydroxy-5-substituted benzamide (B) derivatives as substrate of tyrosinase were measured in mouse melanoma cells. And the bioactivities analyzed using comparative molecular similarity indices analysis (CoMSIA). From the CoMSIA model, when cross-validation value (q
Keywords
- CoMSIA, 3D-QSARs;
- Melanogenesis inhibitor;
- Alkyl-3,4-dihydroxy-5-substituted benzoate;
- N-alkyl-3,4-dihydroxy-5-substituted benzamide